The RECIPES team has developed a guidance for application of the precautionary principle in the EU and consulted various actors from science, business, policy-making and organized civil society for this purpose. The guidance advises on how to deal responsibly with uncertain risks in the development and implementation of technology in the EU. Target groups of this guidance are primarily EU policy makers, EU agencies, and EU policy support organisations and bodies that are concerned with risk regulation or the governance of science, technology and innovation. In addition to the guidance, the RECIPES team has prepared a policy brief as executive summary. The guidance covers three meta-themes: scope of application of the precautionary principle; organisation of expertise for application of the precautionary; and participatory processes to support the application of the precautionary principle. The bulk of the points of the stakeholders who participated in the RECIPES consultation process on how to improve the application of the precautionary principle in the EU, was related to one or more of these three themes.